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KMID : 0191120170320111779
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Journal of Korean Medical Science
2017 Volume.32 No. 11 p.1779 ~ p.1783
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Submillisievert Computed Tomography of the Chest in Contact Investigation for Drug-Resistant Tuberculosis
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Lee Seung-Chul
Yoon Soon-Ho
Goo Jin-Mo
Yim Jae-Joon
Kim Chang-Ki
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Abstract
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Close contacts with infectious tuberculosis (TB) are persons at high risk for developing active disease. We preliminarily introduced submillisievert chest computed tomography (CT) scan (effective dose, 0.19?0.25 millisievert) in a contact investigation of multi-drug resistant (MDR)-TB. Baseline CT scan showed minimal nodules or branching opacities in two of six contacts. A two-month follow-up examination revealed a radiologic progression in contact 1, subsequently having the microbiologic diagnosis of MDR-TB at an asymptomatic early stage, whereas nodules transiently increased after 3 months in contact 2, followed by a decrease after one year. Contact 1 was cured after 1.5-year of anti-MDR-TB treatment. In conclusion, early identification of secondary MDR-TB is feasible with submillisievert chest CT scans in contact investigations of MDR-TB, minimizing of MDR-TB transmission and offering a favorable treatment outcome. This was a clinical trial study and was registered at www.ClinicalTrials.gov (Identifier: NCT02454738).
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KEYWORD
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Tuberculosis, Drug-resistance, Computed Tomography
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